Comparison of Treatment Outcomes in Nonspecific Low-Back Pain Patients With and Without Modic Changes Who Receive Chiropractic Treatment.

Annen Michèle M, Peterson Cynthia C, Humphreys B Kim BK

PubMedClinical StudyReal-world Evidence




Published:2018 09

Created at:

Last revised:2019-11-13

Source:Journal of manipulative and physiological therapeutics (J Manipulative Physiol Ther), volume 41, issue 7, 2018, ISSN: 1532-6586

Publication Country:United States

Publication Type:Journal Article, Research Support, Non-U.S. Gov’t

Keywords:Chiropractic, Diagnostic Imaging, Manipulation, Spinal, Outcome Assessment (Health Care)

MeSH Terms:Adolescent; Adult; Aged; Aged, 80 and over; Disability Evaluation; Female; Humans; Low Back Pain (therapy); Lumbar Vertebrae (diagnostic imaging); Magnetic Resonance Imaging; Male; Manipulation, Spinal; Middle Aged; Pain Measurement; Prospective Studies; Young Adult


OBJECTIVE: The aim of this study was to determine if there was a difference in outcomes in patients with nonspecific low back pain, both with and without Modic changes (MCs), who received chiropractic care.

METHODS: This prospective outcomes study included 112 patients with low back pain without disc herniation on magnetic resonance imaging. All patients were treated with spinal manipulative therapy. At baseline, the numerical rating scale (NRS) and Bournemouth Questionnaire (BQ) for disability were collected. The NRS, BQ, and Patient‘s Global Impression of Change (primary outcome) were collected at the follow-up time points of 1 week, 1 month, and 3 months to assess overall improvement. Magnetic resonance imaging scans were analyzed for the presence of MCs and, if present, classified as Modic I or II. The χ2 test was used to compare the proportion of patients reporting clinically relevantimprovement” between patients with and without MCs and between Modic I and Modic II patients. The unpaired Student t test was used to compare NRS and BQ at baseline and change scores at all follow-up time points.

RESULTS: For the primary outcome measure, the proportion of patients reporting relevantimprovement” (Patient‘s Global Impression of Change), and for the secondary outcome measures (NRS and BQ change scores), there were no significant differences between Modic positive and Modic negative patients or between Modic I and Modic II patients.

CONCLUSION: Neither the presence nor absence of MCs nor the Modic change category were related to treatment outcomes for patients with low back pain without disc herniation who received chiropractic care.

Copyright © 2018. Published by Elsevier Inc.




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